Many studies used a series of experimental methods to study the link between postpartum neurooccurrence and depression in order to exhaust neurooccurrence.
Anti-diabetic drug temozolide (TMZ)
Previously, it has been successfully used as an experimental tool in animals to exhaust adult nerve development and is regularly used in human patients as a standard chemotherapy for brain cancer.
In this study, we wanted to evaluate whether TMZ as a model for chemotherapy treatment would affect the parameters associated with depression in animal models.
It is believed that the prevalence of depression patients is very low, and the rate reported by some studies is as high as 90%.
The results of this study in mice showed that treatment with TMZ protocol similar to human showed behavioral and biochemical changes associated with depression development.
In particular, behavioral results showed a serious defect in the treatment of novelty and a significant increase in cortical steroid response.
A new slice method was used to quantify nerve occurrence, which clearly evaluated the occurrence of the dorsal and abdominal nerves, respectively, showing a significant correlation between the level of abdominal nerve occurrence and the cortical steroid response.
Depression is a complex disease whose neurobiology and its relationship with behavior are only discovered in infancy.
The results of this study suggest that chemotherapy
Decreased neurological occurrence leads to previously unreported behavioral and biochemical consequences.
We believe that these results suggest a biological mechanism that may contribute to the development of depression in patients receiving chemotherapy and be separate from the mental distress caused by cancer diagnosis.